Peripheral Opioid Antagonist Enhances the Effect of Anti-Tumor Drug by Blocking a Cell Growth-Suppressive Pathway In Vivo
Fig 6
Combined use of Doc and MNTX significantly suppressed peritoneal metastasis.
A, representative image of 60As6-GFP cells attached to the mesentery of saline-, Doc- and Doc/MNTX-treated mice. Drug administration started from 7 days to 35 days (saline) and 49 days (Doc or Doc/MNTX) after the inoculation of 60As6-GFP cells. Mice were treated with saline, Doc, or Doc/MNTX 2 times a week. Scale bar, upper: 10 μm, lower: 1 μm. Numbers of single cells (B) and spheroids (C) on the mesentery of Doc- and Doc/MNTX-treated mice 49 days after the inoculation of 60As6-GFP cells. Drug administration started from 7 days to 49 days after inoculation. Mice were treated with saline twice a week. (mean ± SD, n = 6 each, *p<0.05).
