Non-Anticoagulant Fractions of Enoxaparin Suppress Inflammatory Cytokine Release from Peripheral Blood Mononuclear Cells of Allergic Asthmatic Individuals
Fig 5
Time- and target-dependent inhibitory effect of fraction 4.
Effect of fraction 4 on TNF-α release by activated PBMCs of allergic asthmatic subjects (n = 3). (A) Addition of fraction 4 at different time points after the addition of PHA and (B) addition of PHA at different time points after the addition of fraction 4. Data is presented as mean ± SD. *p<0.05 and ***p<0.001 versus PHA only control. (C) Effect of fraction 4 on TNF-α release from activated PBMCs of allergic asthmatic subjects (n = 3) after stimulation with either PHA (10 μg/mL), Con A (10 μg/mL) or PMA (5 ng/mL). Data is presented as mean ± SD. *p<0.05, **p<0.01 and ***p<0.001 versus PHA or Con A or PMA only control respectively.