The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization
Fig 2
MARCKS Effector Domain contains high homology with other putative nuclear localization sequences.
A schematic of the amino acid sequence of the MARCKS ED with alignment to the nuclear localization sequences of DGK-ζ, BASP1, and AKAP12/SSeCKS/Gravin. Blue circles represent lysines, green circles represent phenylalanines, red circles represent serines, while white circles represent other amino acids using single letter abbreviations. The black lines under the MARCKS effector domain amino acid sequence represent sequence homology to DGK-ζ, BASP1, and AKAP12/SSeCKS/Gravin, respectively.
