Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode
Fig 3
Kinetics of inhibition of FAAH by A, (R)-Flu-AM1; B, (S)-Flu-AM1; C, (R)-Ibu-AM5 and D, (S)-Ibu-AM5.
Left panels shown are means ± SEM, N = 3–4, when not enclosed within the symbol, of the FAAH activity at the added concentrations shown of AEA. Right panels show Dixon plots of the mean data. The dotted lines show the projections of the median intersection point on the axes.
