Diagnostic Magnetic Resonance Imaging of Atherosclerosis in Apolipoprotein E Knockout Mouse Model Using Macrophage-Targeted Gadolinium-Containing Synthetic Lipopeptide Nanoparticles
Fig 4
The organ clearance depends on particle shape and composition.
The relative signal-to-noise-ratio (SNR) increase values were calculated for regions of interest in the kidney (A) and the liver (B) of apo E KO mice at 4 h, 24 h, 48 h, 72 h following injection of the equivalent of 0.05 mmol Gd kg −1 of paramagnetic and Rhodamine B-labeled discoidal HDL (dHDL) or spherical HDL (sHDL) containing a 1:1 mixture of oxidized synthetic apo A-I peptides H4 and H6. The data were calculated for each of the timepoints for a representative mouse receiving either dHDL or sHDL using the corresponding T1-weighted images and are represented as percent SNR increase relative to the baseline pre-contrast scan (mean ± SD). Statistical difference between the 4 h and 72 h time points is shown.
