Consistency Analysis of Genome-Scale Models of Bacterial Metabolism: A Metamodel Approach
Fig 5
Workflow diagram of the gap-filling process.
The set of blocked is classified either as non-metablocked or Metablocked. Metablocked (red) reactions are the ones that couldn't be curated on the metamodel and thus are excluded or removed from the models. Non-metablockeds, are reactions found blocked in at least one GSM but actives in the metamodel and thus can be curated in the GSM. gap-filling reactions (green) are the set of reactions that need to be added to a model in order to unblocked the complete set of blocked non-metablocked. Finally, some of the gap-filling reactions can be associated to one or more genes (mapped) whereas others remain orphans.
