The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth
Fig 1
Deletion of Men1 in all pancreatic cells increases ARC mRNA levels preferentially in islets.
A) Endocrine (Endo) and exocrine (Exo) pancreatic tissue from 12 m old mice before (top) and after (bottom) laser capture microdissection. B) qRT-PCR for ARC in mouse pancreatic endocrine tissue from the indicated genotypes. C) qRT-PCR for ARC in mouse pancreatic exocrine tissue from the indicated genotypes. N = 3 mice per genotype. ** P < 0.01 versus Pdx1-Cre. *** P < 0.001 versus Pdx1-Cre, ## P < 0.01 versus Men1 f/f, #### P < 0.0001 versus Men1 f/f.
