The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth
Fig 2
Deletion of Men1 in the parathyroid hormone-secreting cells increases ARC mRNA expression.
A) Parathyroid tissue (inside blue circle) from 12 m old PTH-Cre; Men1 f/f mouse subsequently subjected to laser microdissection. B) qRT-PCR for ARC in parathyroid tissue from the indicated genotypes. N = 3 mice per genotype. **** P < 0.0001 versus PTH-Cre. C) qRT-PCR for ARC in liver tissue from the indicated genotypes. Each bar in panel C represents mRNA samples isolated from a single mouse.
