The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth
Fig 5
Deletion of ARC does not change rates of cellular proliferation and apoptosis in MEN1 insulinomas.
A) Immunostaining of pancreatic tissue from 12 m old mice for Ki-67 (top, green) and TUNEL (bottom, green). β-cells are demarcated by insulin (red) and nuclei are counterstained with DAPI. Scale bar denotes 50 μM. B) Quantification of proliferating cells by Ki-67 staining. C) Quantification of apoptotic cells by TUNEL. No comparisons are significant. Number of mice in each group as indicated.
