Therapeutic Efficacy of an ω-3-Fatty Acid-Containing 17-β Estradiol Nano-Delivery System against Experimental Atherosclerosis
Fig 3
In vivo histological evaluation of systemic administration of 17-βE as a solution and a CREKA-peptide-modified nanoemulsion system on plaque size and lipid content.
(A) H & E staining of the aortic valves and plaque area analysis quantified using Image J (n = 4 independent animals per group). The asterisk represents statistical significance between the untreated treatment group and the different 17-βE solution, 17-βE nanoemulsion and blank nanoemulsion treatment groups (P < 0.05). (B) Oil-red-O staining of the aortic valves and plaque lipid analysis quantified using Image J (n = 4 independent animals per group). The asterisk represents statistical significance between the untreated treatment group and the different 17-βE solution, 17-βE nanoemulsion and blank nanoemulsion treatment groups (P < 0.05).
