The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy
Fig 5
PI3K/Akt signaling in each group.
A: p-Akt/Akt expression from the western blot image of the sham, succinate, and succinate+wortmannin groups (n = 3); *P<0.05 compared to the sham group; #P<0.05 compared to the succinate group. B: GPR91 expression as determined by western blot analysis of the sham, succinate, and succinate+wortmannin groups (n = 3); *P<0.05 compared to the sham group; #P<0.05 compared to the succinate group. C: p-Akt/Akt expression as determined by western blot analysis of the sham, PAB, PAB+succinate, and PAB+succinate+wortmannin groups (n = 3); *P<0.05 compared to the sham group; #P<0.05 compared to the PAB group; &P<0.05, compared to the PAB+succinate group. D: GPR91 expression as determined by western blot analysis of the sham, PAB, PAB+succinate, and PAB+succinate +wortmannin groups (n = 3); *P<0.05 compared to the sham group; #P<0.05 compared to the succinate group; &P<0.05 compared to the PAB+succinate group (n = 3).
