Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice
Fig 1
Gross morphological and functional analysis of Malat-1 WT and KO hearts after TAC.
Increased heart weight/tibia length (A) and diastolic LV wall thickness (B) confirm concentric hypertrophy in both Malat-1 WT and KO mice without effects on diastolic LV inner diameter (C). Decreased fractional shortening (D) and lung congestion with increased lung weight/tibia length in some animals (E) indicate heart failure independent of Malat-1 deficiency. (F) Representative photographs of mouse hearts, Scale bar: 1 cm; *p<0.05, **p<0.01, ****p<0.0001 TAC versus Sham.
