The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury
Fig 5
β2GPI deficient mice and cardiac IRI.
β2GPI -/- mice treated with control sustained the same myocardial infarction size on 1% TTC staining as WT mice. Domain V (n = 6) protects β2GPI -/- mice from cardiac IRI compared with control (n = 11). Reconstitution with rmβ2GPI (n = 6) resulted in similar infarction size to control mice. Individual points represent infarct size as a % of AAR of a single mouse. The horizontal line for each study group represents the mean. NS = not significant.
