The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury
Fig 6
Domain V protects from cardiac IRI in Rag-1 -/- antibody deficient mice reconstituted with natural IgM antibodies.
(A) Rag-1 -/- mice were treated with saline or pooled murine IgM prior to IRI. The mice treated with IgM were further treated with either saline or rhDomain V at the time of reperfusion. Domain V reduced Troponin I levels at 24 h to similar levels to the antibody deficient mice. (B) Treatment with rhDomain V reduced infarction size (as percentage of total LV) in antibody deficient mice reconstituted with pooled IgM. IgM = murine immunoglobulin M. Individual points represent infarct size as a % of LV of a single mouse. The horizontal line for each study group represents the mean.
