The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury
Fig 7
Domain V of β2GPI binds neoepitopes on cardiac ischemic tissue inhibiting IgM NAb binding.
(A) Natural antibodies can bind multiple different epitopes in the setting of cardiac IRI including non-muscle myosin II and β2GPI bound to anionic phospholipids. Domain I of endogenous β2GPI is exposed upon binding of its Domain V to damaged endothelium in the setting of IRI. (B) Domain V binds neoepitopes exposed on the surface of damaged cardiac tissue. This has two effects, prevention of exposure of the Domain I cryptic epitope and binding of anti-β2GPI NAbs. It also prevents other NAbs binding to multiple non-β2GPI neoepitopes.
