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Transgenic Rescue of the LARGE_myd Mouse: A LARGE Therapeutic Window?

Fig 3

The LARGE-LV5 transgene corrects LARGE_myd muscle pathology.

Haematoxylin/Eosin staining of quadriceps muscle from LARGE_myd (a) and LARGE_myd plus the LARGE-LV5 transgene (b). Extent of muscle central nucleation in the genotypes indicated (c). Means+SEM, N = 3. ** P<0.01.

doi: https://doi.org/10.1371/journal.pone.0159853.g003