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Transgenic Rescue of the LARGE_myd Mouse: A LARGE Therapeutic Window?

Fig 4

The LARGE-LV5 transgene corrects LARGE_myd cortical defects.

Haematoxylin/Eosin staining of cortical coronal sections of brains from wild type, WT-LV5, LARGE_myd and LARGE_myd-LV5 mice (as indicated). WT and WT-LV5 mice display normal laminar cortical arrangement, with a clear molecular layer which is lost in LARGE_myd but restored by the LARGE-LV5 transgene (arrowheads). Bar: 200μm.

doi: https://doi.org/10.1371/journal.pone.0159853.g004