Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation
Fig 4
Transgenic mice overexpressing heparanase showed reduced liver hepcidin mRNA and serum protein.
(A) Liver hepcidin mRNA levels of wild type (WT) and transgenic HPA mice (TG-HPA) normalized to Hprt1. The values are expressed as fold change of wild type mice. (B) Quantification of serum hepcidin by SELDI-TOF in the same mice.
