Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation
Fig 5
Transgenic mice overexpressing heparanase showed altered iron homeostasis.
(A) Levels of serum iron in the WT and TG-HPA mice, (B) non-heme liver iron and (C) non-heme spleen iron levels, measured by a spectrophotometric assay. (D) Perl’s stain of spleen sections that showed a lower number of iron granules in TG-HPA compared to WT mice. The sections were counterstained with hematoxylin and eosin
