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Englerin A induces an acute inflammatory response and reveals lipid metabolism and ER stress as targetable vulnerabilities in renal cell carcinoma

Fig 3

Renal cancer cells are highly sensitive to growth inhibition by englerin A and ceramide.

[3H]-Thymidine incorporation was measured in A498 and UO-31 cells treated with 0.1% DMSO (control) or increasing concentrations of englerin A (A) or C8-ceramide (B) for 48 h.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0172632.g003