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A comparative study of the effect of the dose and exposure duration of anabolic androgenic steroids on behavior, cholinergic regulation, and oxidative stress in rats

Fig 2

Anxiogenic-like behavior of rats (n = 10) treated intramuscularly with vehicle (olive oil, 0.2 ml), boldenone (BOL), or stanazolol (ST) once a week according to Protocol I (4 weeks, 5 mg/kg), Protocol II (8 weeks, 2.5 mg/kg), or Protocol III (12 weeks, 1.25 mg/kg) as assessed in the elevated plus maze task. Time spent in the open-arms (A, B, and C), entry to open-arms (D, E, and F), time spent in closed-arms (G, H, and I), and crossing numbers (J; P1, P2 and P3). *Denotes significant difference from the vehicle group. # Denotes significant difference between BOL and ST groups.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0177623.g002