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A comparative study of the effect of the dose and exposure duration of anabolic androgenic steroids on behavior, cholinergic regulation, and oxidative stress in rats

Fig 8

Parameters of oxidative stress in the cerebral cortex of rats (n = 10) treated intramuscularly with vehicle (olive oil, 0.2 ml), boldenone (BOL), or stanazolol (ST) once a week according to Protocol I (4 weeks, 5 mg/kg, graph A), Protocol II (8 weeks, 2.5 mg/kg, graph B), or Protocol III (12 weeks, 1.25 mg/kg, graph C). Reactive oxygen species (ROS) production for Protocol I (A), II (B), and II (C); malondialdehyde (MDA) levels for Protocol I (D), II (E), and III (F); reduced glutathione (GSH) levels for Protocol I (G), II (H), and III (I); non-protein thiol (NPSH) levels for Protocol I (J), II (K), and III (L). *Denotes significant difference from the vehicle group. # Denotes significant difference between BOL and ST groups.

Fig 8

doi: https://doi.org/10.1371/journal.pone.0177623.g008