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Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease

Fig 2

Flowchart of cis-regulating allele-specific DNA methylation SNP candidate selection around IBD susceptibility genes.

SNP, single-nucleotide polymorphism; MSRE, methylation-sensitive restriction enzyme; RAS, relative allele score; IBD, inflammatory bowel disease; (G), genomic DNA; (D), DNA digested MSREs; (U), whole-genome-amplified fully unmethylated DNA digested MSREs.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0194036.g002