Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice
Fig 4
Changes in endothelial tight junctions are observed in multiple regions of the brain following BCAS.
A) Representative images of claudin-5 staining (red) within the cortex, hippocampus and striatum of sham or BCAS-treated (14 days) mice. Scale bar = 100 um. Inset images are a magnified portion to show detail. Scale bar = 300 um. B) Quantification of claudin-5-positive pixels. N = 4–6 C) Quantification of occludin gene expression within the cortex and striatum of sham or BCAS treated (14 day) mice. N = 3 *p < 0.05, **p < 0.01.
