Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice
Fig 6
Cellular proliferation is increased in multiple regions of the brain following BCAS.
A) Representative images of Ki-67 staining (green) and B) quantification of Ki-67-positive pixels in the cortex, hippocampus and striatum of sham and BCAS-treated (14 days) mice. N = 3 *p < 0.05 Scale bar = 100 um. C) Representative images of Ki-67 staining (green) co-labeled (red) with PECAM (endothelial cells), GFAP (astrocytes), CD11b (microglia) and OSP (oligodendrocytes) within the striatum of 14 day BCAS mice. Scale bar = 100 um. Inset images are a magnified portion to show detail. Scale bar = 300 um. Graph shows quantification of the percentage of Ki-67 positive cells co-labelled with PECAM, GFAP, CD11b or OSP from 14 day BCAS mice. N = 3.
