http://orcid.org/0000-0002-8591-0673
Figures
Abstract
Background
Little is known about heart diseases and their treatment in rural sub-Saharan Africa. This study aimed to describe the occurrence, characteristics, and etiologies of heart diseases, and the medication taken before and prescribed after echocardiography in a rural referral Hospital in Tanzania.
Methods
This prospective descriptive cohort study included all adults and children referred for echocardiography. Clinical and echocardiographic data were collated for analysis.
Results
From December 2015 to October 2017, a total of 1’243 echocardiograms were performed. A total of 815 adults and 59 children ≤15 years had abnormal echocardiographic findings; in adults 537/815 (66%) had hypertension, with 230/537(43%) on antihypertensive drugs, and 506/815 (62%) were not on regular cardiac medication; 346/815 (42%) had severe eccentric or concentric left ventricular hypertrophy, and 182/815 (22%) had severe systolic heart failure. Only 44% demonstrated normal left ventricular systolic function. The most frequent heart diseases were hypertensive heart disease (41%), valvular heart disease (18%), coronary heart disease (18%), peripartum cardiomyopathy (7%), and other non-hypertensive dilated cardiomyopathies (6%) in adults, and congenital heart disease (34%) in children. Following echocardiography, 802/815 (98%) adults and 40/59 (68%) children had an indication for cardiac medication, 70/815 (9%) and 2/59 (3%) for oral anticoagulation, and 35/815 (4%) and 23/59 (39%) for cardiac surgery, respectively.
Conclusion
Hypertension is the leading etiology of heart diseases in rural Tanzania. Most patients present with advanced stages of heart disease, and the majority are not treated before echocardiography. There is an urgent need for increased awareness, expertise and infrastructure to detect and treat hypertension and heart failure in rural Africa.
Citation: Raphael DM, Roos L, Myovela V, Mchomvu E, Namamba J, Kilindimo S, et al. (2018) Heart diseases and echocardiography in rural Tanzania: Occurrence, characteristics, and etiologies of underappreciated cardiac pathologies. PLoS ONE 13(12): e0208931. https://doi.org/10.1371/journal.pone.0208931
Editor: Salah A.M. Said, Ziekenhuisgroep Twente, NETHERLANDS
Received: July 20, 2018; Accepted: November 22, 2018; Published: December 26, 2018
Copyright: © 2018 Raphael et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: All relevant data are within the paper and its Supporting Information files.
Funding: We received support from the following foundations: Symphasis Foundation, Zürich, Switzerland, Hella Langer Foundation, Gräfelfing, Germany, and Ernst Göhner Foundation, Zug, Switzerland to MR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Introduction
Non-communicable diseases are underappreciated in countries with a low-middle socio-demographic index (SDI), even though disability adjusted life-years (DALYs, the sum of the years of life lost due to premature mortality and years of life lived with disability) due to non-communicable diseases increased by 54% during the last 25 years [1].
Although DALYs from communicable, maternal, and nutritional diseases still account for more than those from non-communicable diseases in sub-Saharan Africa, cardiovascular diseases are increasingly present among the leading causes of total DALYs in countries with a low SDI [1]. According to World Health Organisation (WHO) estimates, cardiovascular diseases are the second most common cause of death in Africa. In 2015, almost 1.2 million people died because of cardiovascular diseases in Africa, which is more than for malaria and tuberculosis combined [2]. Mortality of patients with heart failure has been reported to be highest in Africa, compared to other low- and middle income regions: The INTER CF prospective cohort study including patients from Asia, South America, Africa, and the Middle East showed a one year overall mortality of 16.5%, but for Africa alone the mortality was estimated at 34% [3]. The most commonly reported etiology of heart failure in low- and middle-income regions is ischemic heart disease, except for the Americas and Africa, where hypertension is the predominant cause [4]. A recent systematic review and meta-analysis of 22 studies from Africa (1999–2017) including 10’098 patients found hypertensive heart disease (39.2%) to be the commonest cause of heart failure, followed by cardiomyopathies (21.4%), and rheumatic heart disease (14.1%). Ischemic heart disease was reported to be rare (7.2%) [5]. However, most patients included were from urban hospitals, and only a minority (603/10’098, 6%) originated from rural areas, where cardiomyopathies and rheumatic heart disease appeared to be most common causes for heart failure in small studies from rural Rwanda and rural Cameroon [6, 7]. In the same review [5], 9 included studies analyzed the use of cardiac medication given at admission or at discharge from a hospital. However, only 11% of the patients represented rural areas from sub-Saharan Africa, and the proportion of patients on cardiac medication at presentation to a clinic was not described yet. In this study, we describe the occurrence, characteristics, and etiologies of heart diseases diagnosed using echocardiography in patients from the rural Kilombero- and Ulanga districts in Tanzania, and describe the medication taken before and prescribed after echocardiography.
Material and methods
Ethics statement
The study was approved by ethics committee in Switzerland (Ethikkommission Nordwest und Zentralschweiz (EKNZ UBE-15/83)) and the ethics committees of the Ifakara Health Institute (Institutional Review Board, IHI/IRB/No 38–2015) as well as the National Institute for Medical Research, Tanzania (Ref. NIMR/HQ/R.8a/Vol. IX/2242). All three committees waived informed consent, to minimize selection bias, and due to the substantial benefit for the study population.
Study site
The St Francis Referral Hospital is situated in Ifakara in Tanzania and serves as a referral center for a rural population of about one million inhabitants form the Kilombero- and Ulanga districts. It has 360 beds and specialized services in internal medicine, surgery, obstetrics, neonatology and gynecology, ophthalmology, pediatrics, and has an HIV and tuberculosis clinic. In September 2015, an emergency department including a triaging system and training of medical staff in emergency medicine, sonography and echocardiography was implemented. Since January 2016, this emergency department has been open 24 hours a day, caring for over 36’000 patients per year, and is the only site in the Kilombero- and Ulanga region where echocardiography is available.
Study design
All symptomatic patients (i.e adults including pregnant women, and children ≤15 years with dyspnea, orthopnoea or chest pain of all ages) who were referred to the emergency department for echocardiography were eligible for this prospective descriptive cohort study. Over 22 consecutive months the medical histories, clinical examination results and echocardiographic data were collected for these patients and collated for analysis.
Data collection
Clinical data (medical history including symptoms and medication, physical examination including weight, height, body surface area, blood pressure (BP) and heart rate) were consecutively collected on a dedicated case report form (EpiData). BP was measured with a manual BP meter in sitting position, after a minimum of 5 minutes of rest. Prior to echocardiography, history taking and physical examination including inspection, palpation of the apex beat, and auscultation of the heart and lungs was performed in all patients by the echocardiographer. Initial electrocardiograms (ECG) and chest x-rays were done according to the decision of the referring clinician.
Echocardiography
Two-dimensional echocardiography with color-, pulse wave (PW)-, continuous wave (CW)- and tissue doppler imaging (TDI) was performed with a Mindray M7 ultrasound machine (Mindray, Shenzhen, China) using a P4-2s phased array transducer. Detailed echocardiographic assessment of ventricular and atrial size, left- and right ventricular systolic and diastolic function, regional wall abnormalities, and valvular structures and function was conducted and interpreted according to recent recommendations and international guidelines [8–15]. End-systolic and end-diastolic left ventricular (LV) volumes and LV ejection fraction (EF) were calculated by the Simpson method of discs. To measure and interpret LV diastolic function and to estimate LV end-diastolic- and left atrial filling pressure (LAP), mitral inflow- (E/A), mitral septal annulus- (e’), and tricuspid regurgitation (TR) velocity, E/e’, left atrium (LA) volume index, and pulmonary venous flow was used. In case of valvular heart disease with mitral valve stenosis or at least moderate mitral valve regurgitation, diastolic function and LAP was considered to be determinable only if Ar-A≥30msec, and in case of depressed EF only, if septal E/e’ >15 [9]. To measure the right ventricular function, tricuspid annular plane systolic excursion (TAPSE), right ventricular systolic excursion velocity by TDI (s’), fractional area change (FAC), and myocardial performance index (MPI) was used. To estimate pulmonary artery pressure, TR velocity, MPI, pulmonary valve acceleration time/right ventricular ejection time (PVAccT/RVET), and deceleration index (DI) was used. The right atrial pressure was estimated by inferior vena cava (IVC) diameter and the presence of its inspiratory collapse. To evaluate the severity of valvular regurgitation, an integrative approach was used, including the proximal isovelocity surface area (PISA) method if appropriate [10]. To quantify mitral stenosis, planimetry of the valve area and mean gradient was used. All echocardiographic procedures were done by the last author, who prescribed all medication, and recommended heart surgery and anticoagulation according to current guidelines [16–20].
Definitions
Hypertension.
Systolic BP >140mmHg or diastolic BP >90mmHg, measured after a minimum of 5 minutes of rest in sitting position, and at least one documented BP of >140/90mmHg at another occasion, or presence of an established antihypertensive therapy and a documented BP of >140/90mmHg in the past [21, 22].
Hypertensive heart disease.
Hypertrophy or concentric remodeling of the left ventricle with or without global systolic or diastolic left ventricular dysfunction in a patient with arterial hypertension, with neither valve disease nor segmental wall motion abnormalities.
Dilated cardiopathy.
Eccentric hypertrophy of the left ventricle and dilated atria or dilated right ventricle.
Valvular heart disease.
Abnormal size and/or function of the heart and a primary abnormality of a valve (i.e. presence of valve regurgitation or stenosis and thickening of cusps, leaflets, or leaflet tips, vegetations or ruptured chordae tendineae).
Rheumatic heart disease.
Definition according to the 2012 world heart federation (WHF) criteria for echocardiographic diagnosis of rheumatic heart disease [23].
Coronary heart disease.
Typical angina pectoris and ventricular dysfunction with segmental hypo- or akinesia which could be attributed to a specific coronary artery with or without typical ECG-findings.
Peripartum cardiomyopathy.
Cardiomyopathy with a reduced left ventricular ejection fraction of <45%, presenting towards the end of the pregnancy or in the months after delivery in a woman without previously known structural heart disease [25].
TB-pericarditis.
Pericardial effusion in a patient with clinically suspected or microbiologically confirmed tuberculosis (TB).
Constrictive pericarditis.
Echocardiographical signs of constriction in a patient with suspected or confirmed TB.
Hypertrophy of the left ventricle in children.
LV mass (LVM)/height2.7 above the 95th percentile [13]; severe LV hypertrophy: LVM of at least 30% above the 95th percentile.
Concentric hypertrophy.
Increased LVM and a relative wall thickness (RWT) ≥0.42; eccentric hypertrophy, increased LVM and RWT <0.42; concentric remodelling, normal LVM with a RWT ≥0.42 [8].
Results
From December 2015 through to October 2017, a total of 1’243 echocardiograms were performed. After exclusion of 278 (22%) echocardiograms of patients with completely normal findings and 64 (5%) echocardiograms with non-relevant findings only (i.e minimal or mild mitral valve regurgitation in presence of normal leaflet morphology, and no other evidence of heart disease), 901 echocardiograms of symptomatic patients with a heart disease were included. After exclusion of 27 follow-up examinations, 874 echocardiograms of 874 patients were analyzed.
Patient characteristics
Table 1 outlines the patient’s characteristics: A total of 815 were adults, and 59 were children ≤15 years. A total of 199/874 (23%) were admitted to the hospital ward. Median age of the adults was 59 years (range 16–98), 329/815 (40%) were male, 282/815 (35%) had overweight or were obese, and 537/815 (66%) had hypertension. A total of 41/815 (5%) adults were HIV positive. At presentation, 506/815 (62%) were not on regular medication. Among those who had hypertension, only 230/537 (43%) took at least one antihypertensive drug, while BP was >140/90mmHg in 358/537 (67%), and BP was ≥160/100mmHg in 287/537 (53%). A total of 68/815 (8.3%) had atrial fibrillation.
The median age of children presenting was 5 years (range 0.003–15), of which 27/59 (46%) were male, and 17/59 (33%) had underweight.
Echocardiographic findings
Table 2 outlines interpretations of echocardiographic findings, which are shown in detail in S1 Table. Only 93/815 (11%) adults had a normal sized left ventricle, and 353/815 (44%) had a normal left ventricular systolic function. On the other hand, 346/815 (42%) had severe eccentric or concentric hypertrophy of the left ventricle, and 182/815 (22%) had severe systolic heart failure.
Etiology of heart diseases
Hypertension was the main cause or a concomitant cause for heart disease in 510/815 (63%) adults. Table 3 and Fig 1 gives an overview of the distribution of different heart diseases in adults and children. In adults, the most frequent heart diseases were hypertensive heart disease (337/815, 41%), valvular heart disease (146/815, 18%), coronary heart disease (145/815, 18%), peripartum cardiomyopathy (56/815, 7%), other non-hypertensive dilated cardiomyopathies (52/815, 6%), and pulmonary heart disease (37/815, 5%).
Distribution of heart diseases in adults (A) and in children (B). HD, heart disease; TB, tuberculosis.
S2 Table outlines detailed echocardiographic findings of adult patients with rheumatic heart disease. Of the 146 adults with valvular heart disease, 68/146 (47%) fulfilled the criteria for rheumatic heart disease according to WHF criteria [23]. Most common was moderate or severe mitral regurgitation, which was present in 40/68 (59%) patients. Out of 16 patients with mitral stenosis, 13 (81%) were moderate or severe.
A total of 48/68 (71%) patients had an impaired left ventricular systolic function, and 32/68 (47%) had an impaired right ventricular function.
S2 Table outlines detailed echocardiographic findings of patients with peripartum cardiomyopathy. Of 56 patients with peripartum cardiomyopathy, 48/56 (86%) had moderate or severe systolic heart failure, and 21/56 (38%) had severe eccentric hypertrophy.
Heart failure with preserved ejection fraction (HFpEF): Of all patients, only 32/815 (4%) had HFpEF (i.e. EF ≥ 50% and elevated LV-filling pressure).
The most frequent heart diseases in children were congenital heart disease (20/59, 34%), valvular heart disease (12/59, 20%), with 5/12 (42%) fulfilling the criteria for rheumatic heart disease, dilated cardiomyopathy (9/59, 15%), and right heart failure due to pulmonal hypertension (7/59, 12%).
Indications for medication and cardiac surgery
After echocardiography, 802/815 (98%) adults and 40/59 (68%) children had an indication for cardiac medication, 70/815 (9%) adults and 2/59 (3%) children for oral anticoagulation, and 35/815 (4%) adults and 23/59 (39%) children for cardiac surgery. In 700/815 (86%) adults and 32/59 (54%) children at least one new drug was added, in 199/815 (24%) adults and 6/59 (10%) children the dose of at least one drug was increased, and in 191/815 (23%) adults and 9/59 (15%) children, at least one drug was stopped.
Fig 2 shows the drugs taken before and prescribed after echocardiography. Most prescribed drugs after echocardiography were ACE-inhibitors, diuretics, and beta-blockers.
Medication taken before and prescribed after echocardiography in adults (A) and in children (B).
Discussion
Of 1’243 echocardiograms performed within 22 consecutive months, 901 (72%) had relevant pathologies. Most patients presented with advanced stages of heart failure. The majority of patients with heart disease had not been treated before echocardiography, although almost all had an indication for treatment. The most frequent heart disease was hypertensive heart disease, followed by valvular-, and coronary heart disease, and cardiomyopathies. More than one third of children had an indication for cardiac surgery, and 9% of the adults for oral anticoagulation. High blood pressure was not well controlled in two thirds of the patients with hypertension. To date, this is the largest prospective cohort study reporting on occurrence, characteristics, and etiologies of heart diseases conducted at a rural site in Africa—our results reflect the extent and burden of heart diseases, and the neglect of their awareness and management in sub-Saharan Africa.
The high frequency of hypertensive heart disease is in line with the recent meta-analysis of 22 African studies in mostly urban patients [5], and stands in contrast to two studies from rural Rwanda and Cameroon, where cardiomyopathies and rheumatic heart disease were more common [6, 7]. We observed more coronary heart disease, less rheumatic heart disease, and less cardiomyopathies than previously reported [5]. However, it is likely that the prevalence of coronary heart disease was underestimated in previous studies, due to inadequate diagnostic methods, a paucity of physicians, and unreliable health statistics [27]. The high occurrence of poorly controlled hypertension, and the high proportion of untreated patients at presentation in our study is in line with a recent large cross-sectional study, which showed a high cumulative prevalence of cardiovascular risk factors in urban and rural Malawi. The crude prevalence of hypertension was 14.7% in the urban area and 13.6% in the rural area, and many people with hypertension (900/2208 (41%) urban and 1188 /1888 (63%) rural) were not overweight or obese. Only 29% were taking regular antihypertensive medication, and less than half of those had a well-controlled BP (i.e. below 140/90mmHg) [28]. A meta-analysis of studies from 2000 to 2013 in sub-Saharan Africa showed that the prevalence of hypertension at ages of 30, 40, 50 and 60 years was 16%, 26%, 35%, and 44%, respectively. Only 7%-56% were aware of their hypertensive status, 18% were receiving antihypertensive drugs, but only 7% had adequately controlled blood pressure [29]. In another observational cross-sectional study in mostly urban areas of 12 sub-Saharan African countries, 77% had uncontrolled hypertension, although 97% were under antihypertensive medication. The proportion of uncontrolled hypertension increased with decreasing level of patient wealth, and higher grade of hypertension was seen in the lower wealth categories [30]. Among other risk factors such as overweight and reduced physical activity, a reduced urine sodium concentrating ability, increased sodium sensitivity, low plasma renin values, mutations of epithelial sodium channels and other genetic factors might contribute to hypertension in Africans [31–33]. Although Africans did not consume more salt than Whites or Indians in a south-African study, they consumed more than 6 grams of salt per day, which is more than recommended by the WHO [34].
In this study, patients presented with advanced stages of heart failure, notably patients with peripartum cardiomyopathy and rheumatic heart disease. In patients with peripartum cardiomyopathy, severe heart failure and increased left ventricular end-diastolic diameter is associated with non-improvement of left ventricular function [35], and in patients with rheumatic heart disease, it is too late for cardiac surgery in case of severe heart failure [17].
We observed only 32 (4%) cases of heart failure with preserved ejection fraction (HFpEF), defined as heart failure with EF≥50% and a conclusively measurable diastolic relaxation impairment of grade 2 or 3 (i.e. elevated left ventricular filling pressure), following recent recommendations [9]. Studies from the USA and Europe indicate that up to 50% of patients with heart failure have preserved ejection fraction [36], and two studies from sub-Saharan Africa and one study including Latin American, middle-eastern, and North African regions reported proportions of 53%-65% of HFpEF in their study populations [37–39]. In most studies including those from Africa, the definition of HFpEF was based on clinical signs and symptoms of heart failure and preserved left ventricular EF, and diastolic function was not reported. If we would use a similar definition of HFpEF, we would count 405 (50%) cases with HFpEF, and if the same echocardiographic criteria would be used as in an older American prospective study, 27% of our patients would have had isolated diastolic dysfunction and HFpEF, compared to 44% in that study [40].
In accordance to the high prevalence of not treated hypertension, the majority of our patients were not treated for heart failure upon presentation–but after echocardiography, patients were not only prescribed additional drugs, but unnecessary drugs were stopped, or doses of established drugs adapted. Moreover, indication for oral anticoagulation and surgery was made. Most prescribed drugs after performed echocardiography were ACE-Inhibitors, diuretics, beta-blockers, and spironolactone. All of these drugs have an impact on morbidity and mortality: ACE-inhibitors, beta-blockers and spironolactone reduce death and hospitalization by about one third each, the latter in patients with severe heart failure only [41]. Before, information on proportions of treated patients with heart failure was lacking for African regions. All studies reporting on medication described drugs given at admission or at discharge from a hospital, or the time of prescription was not defined [5].
Following echocardiography, 9% of the adult patients had an indication for oral anticoagulation. However, to measure international normalized ratio (INR) was not possible in our setting. Direct anticoagulants such as Rivaroxaban are available, but they are not affordable by most of the patients. Thus, we could not anticoagulate patients with atrial fibrillation. Data about the use of anticoagulants in sub-Saharan Africa except from south-Africa are scarce [42]. A survey among cardiologists in Cameroon showed that only one third of patients with an indication for anticoagulation because of atrial fibrillation received anticoagulation [43]. One study done in 6 tertiary hospitals in Nigeria found suboptimal usage of heparin or warfarin to be common, with reduced awareness of direct anticoagulants among residents and consultants [44].
One third of the children had an indication for cardiac surgery. While the outcome of congenital heart diseases such as Tetralogy of Fallot is poor without an intervention (only one fourth reach the age of 10 years)[45], it is excellent after surgical repair [46], and the outcome after mitral valve replacement in children is good, especially for older children [47]. However, given the ratio of one cardiac center per 33.3 to 50.5 million people and only 1.6 open heart operations per million people per year in sub-Saharan Africa [48], patients face a challenge to get cardiac surgery, also because of unaffordably high costs.
The proportion of people living with HIV was 5% in our study population, which corresponds to the national HIV prevalence of 5%[49]. One third of the children had underweight, which is more than the prevalence of underweight in children 0 to 59 months (13.4% (95% CI 12.7–14.1) in the mainland of Tanzania [50]. Underweight in children with heart disease is common, and depends on multiple factors such as severity of cardiac disease, increased energy requirements, decreased nutritional intake, malabsorbtion, and poor utilisation of absorbed nutrition [51].
This study has several limitations: First, we could not follow-up all patients—thus we cannot comment on long-term outcomes and survival rates or adherence to the prescribed medication. Meanwhile, (V.M) was trained in echocardiography, and clinical and echocardiographic follow-up is done. Future trials performed at our site would allow to build a cardiology center offering systematic follow-up and anticoagulation. Second, the diagnosis of coronary heart disease was based on history, clinical examination, electrocardiogram, and echocardiographic findings. In this rural setting, we could neither perform coronary angiography nor myocardial scintigraphy nor stress-echocardiography. Thus, coronary heart disease remained a suspected diagnosis. Third, we did not screen for cardiovascular risk factors other than hypertension and overweight. One cross-sectional study including 9134 people living in Ifakara showed that 5% had diabetes and 30% had hypertension. A total of 17% of men and 2% of women did smoke, and 15% of men and 6% of women consumed alcohol. Only 8% led sedentary lives [52]. Forth, we could not perform myocardial biopsies, and histological determination of the origin of cardiomyopathies was not possible. Finally, existing echocardiographic normograms for chamber size have not been validated for the African population.
This study has several strengths: The sample size is relatively large, compared to other studies; all patients referred for echocardiography were included prospectively, and patients were examined regardless of their wealth status or availability of health insurance. Selection bias could be minimized, as echocardiography is available only at our site for two large rural districts of Tanzania, and virtually all patients referred for echocardiography from these districts were included. We were able to present detailed echocardiographic measurements and interpretations according to the latest recommendations, and medications were prescribed and surgery recommended following current international guidelines.
In conclusion, hypertension is extremely common and mostly not controlled in rural Tanzania. The leading cause for heart disease in this setting is hypertension. Most patients presented with advanced stages of heart diseases, and the majority was not treated for heart failure before echocardiography. There is an urgent need for community education to improve awareness and to prevent hypertension, for trained staff, and for infrastructure to manage hypertension and heart failure in rural Africa.
Supporting information
S1 Table. Detailed echocardiographic findings of all patients.
LVEDD: left ventricular end-diastolic diameter; IVSd: intraventricular septum in diastole; PWd: posterior wall in diastole; LV: left ventricle; RWT: relative wall thickness; LVOT: left ventricular outflow tract; LA: right atrium; LAVI: left atrial volume index; RA: right atrium; EF: ejection fraction; TAPSE: tricuspid annular plane systolic excursion; FAC: fractional area change; MV: mitral valve; DT: deceleration time; TR: tricuspid regurgitation; Pvein: pulmonary vein. N/A, not applicable. The numbers (n = )/(n = ) indicate of how many adults and children, data were available. * Cantinotti et al 2014 [14].
https://doi.org/10.1371/journal.pone.0208931.s001
(DOCX)
S2 Table. Echocardiographic findings in adults (n = 815) with rheumatic heart disease and peripartum cardiomyopathy.
LVEDD: left ventricular end-diastolic diameter; IVSd: intraventricular septum in diastole; PWd: posterior wall in diastole; LV: left ventricle; RWT: relative wall thickness; LVOT: left ventricular outflow tract; LA: right atrium; LAVI: left atrial volume index; RA: right atrium; EF: ejection fraction; TAPSE: tricuspid annular plane systolic excursion; FAC: fractional area change; MV: mitral valve; DT: deceleration time; TR: tricuspid regurgitation; Pvein: pulmonary vein. The numbers (n = )/(n = ) indicate for how many adults and children, data were available.
https://doi.org/10.1371/journal.pone.0208931.s002
(DOCX)
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