Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells
Fig 1
The IL-6/IL-6R interface site I is not conserved between human and murine IL-6R.
(A) Alignment of the amino acid sequence of the D2 and D3 domains from human and murine IL-6R. Residues previously described to be involved in IL-6 binding are highlighted. (B) Ribbon representation of the human IL-6R D2 and D3 domain structure [17, 18]. (left: front view; right: side view). Regions which are in involved in binding to site I of IL-6 are depicted in green. Amino acid residues in these loop regions that are different in the mouse IL-6R are colored in blue.
