The soluble VEGF receptor sFlt-1 contributes to endothelial dysfunction in IgA nephropathy
Fig 7
JC-1 monomer increased with the stimulation of sFlt-1 and decreased after administration of Z-LEHD-FMK in HUVECs.
A: Effect of Z-LEHD-FMK on sFlt-1-induced disruption of mitochondrial membrane potential in HUVECs. B: statistical result of the percentage of JC-1 monomer in different groups. HUVECs with low ΔΨm increased from 7.63% in untreated cells to 21.33% in cells treated with 100 ng/ml sFlt-1, and further increased to 24.5% in cells with 1000 ng/ml sFlt-1. These effects were alleviated by addition of Z-LEHD-FMK.
