Figures
The incorrect version of Figure 5 was published. The icons showing RvHJn9 and RvHJn11 in panel C are now consistent with the icons in panel G. Please see the corrected figure here.
The growth curves of each chimeric virus, RvJXwn and RvHB-1/3.9 in MARC-145 cells (A, B, C and D) and in primary PAMs (E, F, G and H) are shown. Virus titers from 12 h to 96 h pi were determined by microtitration infectivity assays. The data are shown as the means ± standard deviations (error bars) from three independent trials. Asterisk (*) indicates a significant difference in virus titers between RvJXwn (red) and RvJHn9 (black), or RvJHn9n10 (green), or between RvHB-1/3.9 (blue) and RvHJn9 (black) or RvHJn9n10 (green) (*P<0.05; **P<0.01; ***P<0.001). Pound (#) indicates a significant difference between RvJXwn and RvJHn10 (light blue) or RvJHn9n10n11 (yellow), or between RvHB-1/3.9 and RvHJn10 (light blue) or RvHJn9n10n11 (yellow) (##P<0.01; ###P<0.001). Phi (Φ) indicates a significant difference between RvHB-1/3.9 and RvHJn11 (gray) (ΦΦP<0.01; ΦΦΦP<0.001). Delta (δ) indicates a significant difference between RvHB-1/3.9 and RvHJn12 (gray) (δP<0.05; δδP<0.01). doi:10.1371/journal.ppat.1004216.g005
The incorrect version of Figure 6 was published. The authors have changed the vertical arrangement of panel B, C, D, E and F to a horizontal style, and moved the graphs of clinical sign scores to the front of the graphs of average daily gains. Please see the corrected figure here.
The body temperatures, average clinical scores and average daily gains (ADG) of piglets inoculated with the rescued viruses with the RvJXwn backbone (A, C and E) or with the RvHB-1/3.9 backbone (B, D and F) are shown. The data are shown as the means ± standard deviations (error bars). The clinical scoring included the gross clinical score (GCS), respiratory clinical score (RCS) and nervous signs score (NSS). Total scores for each piglet represented the sum of the GCS, RCS and NSS. An additional five score was calculated in the total scores when the piglet died. Each piglet was scored from 0–20, and the mean values of day 1 to 4 pi, 5 to 8 pi, 9 to 12 pi, 13 to 15 pi, 16 to 18 pi and 19 to 21 pi were calculated. Asterisk indicates a significant difference between the chimeric virus and its parental backbone virus, RvJXwn or RvHB-1/3.9 (*P<0.05; **P<0.01; ***P<0.001). doi:10.1371/journal.ppat.1004216.g006
The incorrect version of Figure 7 was published. The authors have corrected the designations of rescued viruses with RvHB-1/3.9 as the backbone in the mortality table (the lower left of the figure). Please see the corrected figure here.
The mortalities and survival curves of piglets infected with rescued viruses in each group are shown (n = 5). doi:10.1371/journal.ppat.1004216.g007
Reference
Citation: The PLOS Pathogens Staff (2014) Correction: Nsp9 and Nsp10 Contribute to the Fatal Virulence of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Emerging in China. PLoS Pathog 10(8): e1004344. https://doi.org/10.1371/journal.ppat.1004344
Published: August 8, 2014
Copyright: © 2014 The PLOS Pathogens Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.