Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins
Fig 1
The SLFN11 gene has evolved under positive selection in primates.
(A) A phylogeny of the primate SLFN11 gene sequences used in this analysis. Sequences obtained from online databases are indicated with asterisks, the others were generated in this study. (B) Table summarizing the likelihood ratio test between the M8 and M8a models in PAML. The 2ΔlnL value (twice the difference in the natural log of the likelihoods) for M8 versus M8a is shown, along with the p-value with which the neutral model M8a is rejected in favor of the model of positive selection. The tree length of the SLFN11 gene alignment was 0.65, and 7.6% of codons were assigned a dN/dS = 3.8. PAML analysis was repeated using different codon models (f61, 3x4) and different ω0 seed values, and in all cases results converged. (C) Residues corresponding to codons with dN/dS > 1 are indicated on a schematic of the Schlafen11 protein.
